Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …

Human Ku70 is a well-known endogenous nuclear protein involved in the non-homologous
end joining pathway to repair double-stranded breaks in DNA. However, Ku70 has been …

New genetic tools are needed to understand the functional interactions between HIV and
human host factors in primary cells. We recently developed a method to edit the genome of …

Background HIV-1 integration results in genomic DNA gaps that are repaired by cellular
DNA repair pathways. This step of the lentiviral life cycle remains poorly understood despite …

Human immunodeficiency virus (HIV) continues to be a global health challenge, with over
38 million people infected by the end of 2022. HIV-1, the predominant strain, primarily …

RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to
facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an …

The DNA dependent protein kinase (DNA-PK) is a trimeric nuclear complex consisting of a
large protein kinase and the Ku heterodimer. The kinase activity of DNA-PK is required for …

Abstract Human Ku70/Ku80 protein is known to influence HIV-1 replication. One of the
possible reasons may be the protection of integrase from proteasomal degradation by Ku70 …

The DNA-PK complex is the major component of the predominant mechanism of DSB repair
in humans. In addition, this complex is involved in many other processes such as DNA …

Essential host cofactors in retrovirus replication bind cis-acting sequences in the 5′
untranslated region (UTR). Although host RBPs are crucial to all aspects of virus biology …