CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

Asthma and chronic obstructive pulmonary disease (COPD) are obstructive airway disorders
which differ in their underlying causes and phenotypes but overlap in patterns of …

It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …

Why NAD+ Declines during Aging: It’s Destroyed: Cell Metabolism Skip to Main Content
Advertisement Cell Metabolism This journal offers authors two options (open access or …

Mitochondria are the critical organelles for energy metabolism and cell survival in eukaryotic
cells. Recent studies demonstrated that mitochondria can intercellularly transfer between …

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in
hepatocytes. CD38 was initially identified as a lymphocyte surface antigen and then has …

A clear understanding of the origins of cancer is the basis of successful strategies for
effective cancer prevention and management. The origin of cancer at the molecular and …

This medical review addresses the hypothesis that CD38/NADase is at the center of a
functional axis (ie, intracellular Ca2+ mobilization/IFNγ response/reactive oxygen species …

Chronic lymphocytic leukemia (CLL) cells rapidly undergo apoptosis in vitro, suggesting that
the in vivo microenvironment provides crucial antiapoptotic signals. Overexpression of the …

As we age, our body experiences chronic, systemic inflammation contributing to the
morbidity and mortality of the elderly. The senescent immune system has been described to …