In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint
(IC) proteins, which act as a potent suppressor of the immune system by a myriad of …

Immune cell infiltration into solid tumors, their movement within the tumor microenvironment
(TME), and interaction with other immune cells are controlled by their directed migration …

Despite tremendous gains in the molecular understanding of exocrine pancreatic cancer,
the prognosis for this disease remains very poor, largely because of delayed disease …

Recently, immune checkpoint inhibitors (ICIs) therapy has become a promising therapeutic
strategy with encouraging therapeutic outcomes due to their durable anti-tumor effects …

Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred
via a variety of receptors into and between cells, serum, bile, and cerebrospinal fluid. It has …

Abstract Programmed cell death 1 (PD-1) inhibitors have limited effect in pancreatic ductal
adenocarcinoma (PDAC), underscoring the need to co-target alternative pathways. CXC …

For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Objective Programmed cell death protein 1 (PD-1) checkpoint inhibition and adoptive
cellular therapy have had limited success in patients with microsatellite stable colorectal …

Pancreatic ductal adenocarcinoma carries a dismal prognosis, and outcomes have
improved little with modern therapeutics. Checkpoint-based immunotherapy has failed to …