Immunotherapies for hepatocellular carcinoma

JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …

Hepatocellular carcinoma: new developments

P Ganesan, LM Kulik - Clinics in liver disease, 2023 - liver.theclinics.com
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related mortality
worldwide and a leading cause of death in cirrhosis. The prognosis in HCC is poor, with …

[HTML][HTML] Tislelizumab combined with chemotherapy as neoadjuvant therapy for surgically resectable esophageal cancer: A prospective, single-arm, phase II study (TD …

X Yan, H Duan, Y Ni, Y Zhou, X Wang, H Qi… - International Journal of …, 2022 - Elsevier
Background Clinical benefit of neoadjuvant immunotherapy in resectable esophageal
squamous cell carcinoma (ESCC). remains unclear. This study evaluated the efficacy and …

Evidence-based management of hepatocellular carcinoma: systematic review and meta-analysis of randomized controlled trials (2002–2020)

PK Haber, M Puigvehí, F Castet, V Lourdusamy… - Gastroenterology, 2021 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer-related
mortality, with a rapidly changing landscape of treatments. In the past 20 years, numerous …

Adjuvant sintilimab in resected high-risk hepatocellular carcinoma: a randomized, controlled, phase 2 trial

K Wang, YJ Xiang, HM Yu, YQ Cheng, ZH Liu, YY Qin… - Nature Medicine, 2024 - nature.com
Hepatocellular carcinoma (HCC), particularly when accompanied by microvascular invasion
(MVI), has a markedly high risk of recurrence after liver resection. Adjuvant immunotherapy …

[HTML][HTML] Cancer nanomedicine in preoperative therapeutics: Nanotechnology-enabled neoadjuvant chemotherapy, radiotherapy, immunotherapy, and phototherapy

X Qu, D Zhou, J Lu, D Qin, J Zhou, HJ Liu - Bioactive materials, 2023 - Elsevier
Surgical resection remains a mainstay in the treatment of malignant solid tumors. However,
the use of neoadjuvant treatments, including chemotherapy, radiotherapy, phototherapy …

PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells

Q Li, L Zhang, W You, J Xu, J Dai, D Hua… - Nature …, 2022 - nature.com
Abstract Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but
only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 …

NASH and hepatocellular carcinoma: immunology and immunotherapy

M Pinter, DJ Pinato, P Ramadori… - Clinical Cancer Research, 2023 - AACR
The last 10 years have revolutionized our basic understanding of nonalcoholic fatty liver
disease and consequent liver cancer. It has become clear that several innate and adaptive …

Intention-to-treat outcomes of patients with hepatocellular carcinoma receiving immunotherapy before liver transplant: The multicenter VITALITY study

P Tabrizian, ML Holzner, V Ajmera, AK Kim, K Zhou… - Journal of …, 2024 - Elsevier
Background & Aims The use of immune checkpoint inhibitors (ICIs) in patients with
advanced hepatocellular carcinoma (HCC) has become widespread with encouraging …

Neoadjuvant cemiplimab for resectable hepatocellular carcinoma: a single-arm, open-label, phase 2 trial

TU Marron, MI Fiel, P Hamon, N Fiaschi… - The Lancet …, 2022 - thelancet.com
Background Surgical resection of early stage hepatocellular carcinoma is standard clinical
practice; however, most tumours recur despite surgery, and no perioperative intervention …