[HTML][HTML] Engineering organoids
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …
enormous interest for modelling tissue development and disease, and for personalized …
Pancreatic cancer evolution and heterogeneity: integrating omics and clinical data
AA Connor, S Gallinger - Nature Reviews Cancer, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC), already among the deadliest epithelial
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
malignancies, is rising in both incidence and contribution to overall cancer deaths. Decades …
[HTML][HTML] Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
CODA: quantitative 3D reconstruction of large tissues at cellular resolution
A central challenge in biology is obtaining high-content, high-resolution information while
analyzing tissue samples at volumes relevant to disease progression. We address this here …
analyzing tissue samples at volumes relevant to disease progression. We address this here …
KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells
Summary The KRAS G12D mutation is present in nearly half of pancreatic adenocarcinomas
(PDAC). We investigated the effects of inhibiting the KRAS G12D mutant protein with …
(PDAC). We investigated the effects of inhibiting the KRAS G12D mutant protein with …
[HTML][HTML] The molecular biology of pancreatic adenocarcinoma: translational challenges and clinical perspectives
S Wang, Y Zheng, F Yang, L Zhu, XQ Zhu… - Signal transduction and …, 2021 - nature.com
Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …
correspondence between disease mortality and incidence. Furthermore, it is usually …
[HTML][HTML] Human organoid models to study SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …
[HTML][HTML] Overcoming cancer therapeutic bottleneck by drug repurposing
Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …
the development of the alternative strategy of drug repurposing, the development of old …
[HTML][HTML] Human disease models in drug development
A Loewa, JJ Feng, S Hedtrich - Nature reviews bioengineering, 2023 - nature.com
Biomedical research is undergoing a paradigm shift towards approaches centred on human
disease models owing to the notoriously high failure rates of the current drug development …
disease models owing to the notoriously high failure rates of the current drug development …
[HTML][HTML] Tumor organoids: Opportunities and challenges to guide precision medicine
Tumor organoids have been proposed as a model system for precision medicine. The ability
of tumor organoids to retain characteristics of the original tumor makes them unique for …
of tumor organoids to retain characteristics of the original tumor makes them unique for …