G protein-coupled receptor kinase 2 (GRK2) is a central signaling node involved in the
modulation of many G protein-coupled receptors (GPCRs) and also displaying regulatory …

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

Increasing evidences point to G protein-coupled receptor kinases (GRKs), a subfamily of
protein kinase A/G/C-like kinases, as relevant players in cancer progression, in a cell-type …

Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) regulate gene and
protein expression by exerting an influence on transcriptional and post-transcriptional …

Globally, hepatocellular carcinoma (HCC) is one of the most common causes of cancer-
associated mortalities. It has a high rate of metastasis and recurrence, which predict a poor …

Kaposi's sarcoma (KS) is a highly disseminated angiogenic tumor of endothelial cells linked
to infection by Kaposi's sarcoma-associated herpesvirus (KSHV). KSHV encodes more than …

In the acute inflammatory phase following tissue damage, cells of the innate immune system
are rapidly recruited to sites of injury by pro-inflammatory mediators released at the wound …

Since their early 1990s, the chemokine receptor family of G protein-coupled receptors
(GPCRs) has been the source of much pharmacological endeavour. Best known for their key …

The development of small-molecule inhibitors targeting G protein-coupled receptor kinase 2
(GRK2) and G protein-coupled receptor kinase 5 (GRK5) for the treatment of chronic …