In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells
(HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two …

Liver disease is prevalent worldwide. When it reaches the end stage, mortality rises to 50%
or more. Although liver transplantation has emerged as the most efficient treatment for end …

Lineage tracing reveals hematopoietic stem cell (HSC) fates, while single-cell RNA
sequencing identifies snapshots of HSC transcriptomes. To obtain information on fate plus …

Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart native
lineage pathways emanating from HSCs and define their physiological regulation by …

The exact localization of hematopoietic stem cells (HSCs) in their native bone marrow (BM)
microenvironment remains controversial, because multiple cell types have been reported to …

Multinucleated skeletal muscle cells need to acquire additional nuclei through fusion with
activated skeletal muscle stem cells when responding to both developmental and adaptive …

Human hematopoietic stem cells (HSCs), like their counterparts in mice, comprise a
functionally and molecularly heterogeneous population of cells throughout life that …

A tendon's ordered extracellular matrix (ECM) is essential for transmitting force but is also
highly prone to injury. How tendon cells embedded within and surrounding this dense ECM …

Hematopoietic stem cells (HSCs) are the ultimate source of blood and immune cells, and
transplantation reveals their unique potential to regenerate all blood lineages lifelong. HSCs …

In mammalian cells genes that are in close proximity can be transcriptionally coupled:
silencing or activating one gene can affect its neighbors. Understanding these dynamics is …