Aim Lipodystrophy syndromes are rare heterogeneous disorders characterized by
deficiency of adipose tissue, usually a decrease in leptin levels and, frequently, severe …

The chylomicronemia syndrome is characterized by severe hypertriglyceridemia and fasting
chylomicronemia and predisposes affected individuals to acute pancreatitis. When due to …

Lipodystrophies have been recognized since at least the nineteenth century and, despite
their rarity, tended to attract considerable medical attention because of the severity and …

The chylomicronemia syndrome occurs when triglyceride levels are severely elevated
(usually> 16.95 mmol/L [1500 mg/dL]) and is characterized by such clinical features as …

Type 2 familial partial lipodystrophy (FPLD2) is a laminopathic lipodystrophy due to
pathogenic variants in the LMNA gene. Its rarity implies that it is not well-known. The aim of …

Purpose To evaluate the effects of metreleptin in patients with partial lipodystrophy (PL).
Methods Patients aged≥ 6 months with PL, circulating leptin< 12.0 ng/mL, and diabetes …

Context Partial lipodystrophy (PL) is associated with metabolic co‐morbidities but may go
undiagnosed as the disease spectrum is not fully described. Objective The objective of the …

Lipodystrophy syndromes are a heterogeneous group of diseases, characterized by
selective absence of adipose tissue. In one sense, these diseases are lipid-partitioning …

We have reviewed the genetic basis of chylomicronaemia, the difference between
monogenic and polygenic hypertriglyceridaemia, its effects on pancreatic, cardiovascular …

Insulin resistance underpins the link between obesity and most of its associated metabolic
disorders including type 2 diabetes, fatty liver disease, dyslipidaemia and cardiovascular …