Diabetic kidney disease (DKD) remains the leading cause of the end-stage renal disease
and is a major burden on the healthcare system. The current understanding of the …

The G protein-coupled receptor (GPCR) protease-activated receptor 1 (PAR1) is a
therapeutic target that was originally pursued with the aim of restricting platelet activation …

Diabetes mellitus is a metabolic disease largely due to lifestyle and nutritional imbalance,
resulting in insulin resistance, hyperglycemia and vascular complications. Diabetic kidney …

Tissue factor (TF), which is a member of the cytokine receptor family, promotes coagulation
and coagulation-dependent inflammation. TF also exerts protective effects through unknown …

There is clinical evidence that increased urinary serine proteases are associated with the
disease severity in the setting of diabetic nephropathy (DN). Elevation of serine proteases …

Podocyte injury is involved in the onset and progression of various kidney diseases. We
previously demonstrated that the transcription factor, old astrocyte specifically induced …

Aims: The pathogenesis of diabetic cardiomyopathy (DCM) is complex and the detailed
mechanism remains unclear. Coagulation protease activated Protein C (aPC) has been …

Focal segmental glomerulosclerosis (FSGS), a common cause of primary
glomerulonephritis, has a poor prognosis and is pathologically featured by tubulointerstitial …

Diabetic kidney disease (DKD) is a serious microvascular complication of diabetes and is
the leading cause of end-stage renal disease (ESRD). Persistent proteinuria is an important …

Recurrent spontaneous or trauma-related bleeding into joints in hemophilia leads to
hemophilic arthropathy (HA), a debilitating joint disease. Treatment of HA consists of …