Advances in research and technology has increased our quality of life, allowed us to combat
diseases, and achieve increased longevity. Unfortunately, increased longevity is …

Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …

Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

The LDL receptor-related protein (originally called LRP, but now referred to as LRP1) is a
large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of …

Recent research has identified some key players involved in the proteolytic processing of
amyloid precursor protein (APP) to amyloid β-peptide, the principal component of the …

Susceptibility to Alzheimer's disease (AD) is governed by multiple genetic factors.
Remarkably, the LDL receptor–related protein (LRP) and its ligands, apoE and α2M, are all …

One of the theories involved in the etiology of Alzheimer's disease (AD) is the oxidative
stress hypothesis. The amyloid β-peptide (Aβ), a hallmark in the pathogenesis of AD and the …

The midkine (MK) family consists of only two members, namely heparin-binding growth
factors MK and pleiotrophin (PTN). During embryogenesis, MK is highly expressed in the …

The ϵ4 allele of apolipoprotein E (apoE) is a risk factor for Alzheimer's disease (AD),
perhaps through effects on amyloid-β (Aβ) metabolism. Detailed analyses of various Aβ …

Apolipoprotein (apo) E4 is a major risk factor for Alzheimer's disease, and many studies
have suggested that apoE has isoform-specific effects on the deposition or clearance of …