BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity

P Kowiański, G Lietzau, E Czuba, M Waśkow… - Cellular and molecular …, 2018 - Springer
Brain-derived neurotrophic factor (BDNF) is one of the most widely distributed and
extensively studied neurotrophins in the mammalian brain. Among its prominent functions …

Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience

JC Udeochu, S Amin, Y Huang, L Fan, ERS Torres… - Nature …, 2023 - nature.com
Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years,
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …

A neuroscientist's guide to transgenic mice and other genetic tools

S Navabpour, JL Kwapis, TJ Jarome - Neuroscience & Biobehavioral …, 2020 - Elsevier
The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …

[HTML][HTML] Cell-type specialization is encoded by specific chromatin topologies

W Winick-Ng, A Kukalev, I Harabula, L Zea-Redondo… - Nature, 2021 - nature.com
Abstract The three-dimensional (3D) structure of chromatin is intrinsically associated with
gene regulation and cell function,–. Methods based on chromatin conformation capture have …

A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data

Q Wang, R Chen, F Cheng, Q Wei, Y Ji, H Yang… - Nature …, 2019 - nature.com
Genome-wide association studies (GWAS) have identified more than 100 schizophrenia
(SCZ)-associated loci, but using these findings to illuminate disease biology remains a …

Development and plasticity of the corpus callosum

NS De León Reyes, L Bragg-Gonzalo… - Development, 2020 - journals.biologists.com
The corpus callosum (CC) connects the cerebral hemispheres and is the major mammalian
commissural tract. It facilitates bilateral sensory integration and higher cognitive functions …

A gene expression atlas for different kinds of stress in the mouse brain

T Flati, S Gioiosa, G Chillemi, A Mele, A Oliverio… - Scientific Data, 2020 - nature.com
Stressful experiences are part of everyday life and animals have evolved physiological and
behavioral responses aimed at coping with stress and maintaining homeostasis. However …

Differential regulation of the BDNF gene in cortical and hippocampal neurons

EE Esvald, J Tuvikene, A Moistus… - Journal of …, 2022 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is a widely expressed neurotrophin that supports
the survival, differentiation, and signaling of various neuronal populations. Although it has …

The dynamics of chromatin architecture in brain development and function

I Harabula, A Pombo - Current opinion in genetics & development, 2021 - Elsevier
The brain comprises many different cell types with specialized functions which respond and
adapt to the continuously changing environment, through tight spatiotemporal regulation of …

Natural history and genotype‐phenotype correlations in 72 individuals with SATB2‐associated syndrome

YA Zarate, CL Smith‐Hicks, C Greene… - American Journal of …, 2018 - Wiley Online Library
SATB2‐associated syndrome (SAS) is an autosomal dominant disorder characterized by
significant neurodevelopmental disabilities with limited to absent speech, behavioral issues …