[HTML][HTML] Circulating microRNAs as potential biomarkers for psychiatric and neurodegenerative disorders

MMJ Van den Berg, J Krauskopf, JG Ramaekers… - Progress in …, 2020 - Elsevier
Circulating microRNAs (cimiRNAs) are a class of non-encoding RNAs found in bodily fluids
such as blood, cerebrospinal fluid (CSF) and tears. CimiRNAs have been implicated as …

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

M Yuan, B Yang, G Rothschild, JJ Mann… - Signal transduction and …, 2023 - nature.com
Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Epigenetic inheritance: concepts, mechanisms and perspectives

I Lacal, R Ventura - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Parents' stressful experiences can influence an offspring's vulnerability to many pathological
conditions, including psychopathologies, and their effects may even endure for several …

Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis

ZX Wei, GJ Xie, X Mao, XP Zou, YJ Liao… - …, 2020 - nature.com
Exosomal microRNAs (miRNAs) have been suggested to participate in the pathogenesis of
neuropsychiatric diseases, but their role in major depressive disorder (MDD) is unknown …

Cannabidiol as a potential treatment for anxiety and mood disorders: molecular targets and epigenetic insights from preclinical research

PA Melas, M Scherma, W Fratta, C Cifani… - International journal of …, 2021 - mdpi.com
Cannabidiol (CBD) is the most abundant non-psychoactive component of cannabis; it
displays a very low affinity for cannabinoid receptors, facilitates endocannabinoid signaling …

Exosomes, DAMPs and miRNA: features of stress physiology and immune homeostasis

M Fleshner, CR Crane - Trends in immunology, 2017 - cell.com
Psychological/physical stressors and local tissue damage increase inflammatory proteins in
tissues and blood in humans and animals, in the absence of pathogenic disease. Stress …

Similarly in depression, nuances of gut microbiota: Evidences from a shotgun metagenomics sequencing study on major depressive disorder versus bipolar disorder …

H Rong, X Xie, J Zhao, W Lai, M Wang, D Xu… - Journal of psychiatric …, 2019 - Elsevier
Background To probe the differences of gut microbiota among major depressive disorder
(MDD), bipolar disorder with current major depressive episode (BPD) and health …

[HTML][HTML] Sex differences in the blood–brain barrier: implications for mental health

L Dion-Albert, LB Binder, B Daigle, A Hong-Minh… - Frontiers in …, 2022 - Elsevier
Prevalence of mental disorders, including major depressive disorder (MDD), bipolar
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …

Are the epigenetic changes predictive of therapeutic efficacy for psychiatric disorders? A translational approach towards novel drug targets

V Micale, M Di Bartolomeo, S Di Martino, T Stark… - Pharmacology & …, 2023 - Elsevier
The etiopathogenesis of mental disorders is not fully understood and accumulating evidence
support that clinical symptomatology cannot be assigned to a single gene mutation, but it …

MicroRNAs and exosomes in depression: potential diagnostic biomarkers

J Tavakolizadeh, K Roshanaei… - Journal of Cellular …, 2018 - Wiley Online Library
Depression is known as one of important psychiatric disorders which could be associated
with disability among various populations. Diagnostic and statistical manual of mental …