Hepatitis B virus (HBV) specifically infects hepatocytes and causes severe liver diseases.
The HBV life cycle is unique in that the genomic DNA (relaxed-circular partially double …

About 250 million people worldwide are chronically infected with Hepatitis B virus (HBV),
contributing to a large burden on public health. Despite the existence of vaccines and …

Hepatitis B virus (HBV) infection is a major driver of hepatocarcinogenesis. Ferroptosis is a
type of iron-mediated cell death that can suppress liver transformation. Previous studies …

Background Hepatocellular carcinoma (HCC) is the most common malignant liver tumor with
poor clinical outcomes. Increasing amount of long non-coding RNAs (lncRNAs) have been …

We aimed to determine the surveillance performance of alpha‐fetoprotein (AFP), lectin‐
reactive AFP (AFP‐L3), des‐gamma‐carboxy prothrombin (DCP), and their combinations for …

Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post‐
translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone …

MYH9 has dual functions in tumors. However, its role in inducing tumor stemness in
hepatocellular carcinoma (HCC) is not yet determined. Here, we found that MYH9 is an …

Background Hepatitis B virus covalently closed circular DNA (HBV cccDNA) is assembled by
histones and non-histones into a chromatin-like cccDNA minichromosome in the nucleus …

Ubiquitination is a prominent posttranslational modification, in which the ubiquitin moiety is
covalently attached to a target protein to influence protein stability, interaction partner and …

Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes,
and the enzymes involved are tightly regulated by multiple factors including posttranslational …