Radiochemistry for positron emission tomography

J Rong, A Haider, TE Jeppesen, L Josephson… - Nature …, 2023 - nature.com
Positron emission tomography (PET) constitutes a functional imaging technique that is
harnessed to probe biological processes in vivo. PET imaging has been used to diagnose …

Applications of fluorine in medicinal chemistry

EP Gillis, KJ Eastman, MD Hill… - Journal of medicinal …, 2015 - ACS Publications
The role of fluorine in drug design and development is expanding rapidly as we learn more
about the unique properties associated with this unusual element and how to deploy it with …

Self‐protective room‐temperature phosphorescence of fluorine and nitrogen codoped carbon dots

P Long, Y Feng, C Cao, Y Li, J Han, S Li… - Advanced Functional …, 2018 - Wiley Online Library
The unstable triplet excited state is a core problem when developing self‐protective room
temperature phosphorescence (RTP) in carbon dots (CDs). Here, fluorine and nitrogen …

18F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography

S Preshlock, M Tredwell, V Gouverneur - Chemical reviews, 2016 - ACS Publications
Diverse radiochemistry is an essential component of nuclear medicine; this includes
imaging techniques such as positron emission tomography (PET). As such, PET can track …

Monofluorination of organic compounds: 10 years of innovation

PA Champagne, J Desroches, JD Hamel… - Chemical …, 2015 - ACS Publications
Taking into account the vast arrays of fluorinated motifs known, 11 this review will be limited
to the monofluorination of organic compounds, ie, synthetic methods allowing the …

Highlights on US FDA-approved fluorinated drugs over the past five years (2018–2022)

S Ali, J Zhou - European journal of medicinal chemistry, 2023 - Elsevier
The objective of this review is to provide an update on the fluorine-containing drugs
approved by US Food and Drug Administration in the span of past five years (2018–2022) …

Introduction of fluorine and fluorine‐containing functional groups

T Liang, CN Neumann, T Ritter - … Chemie International Edition, 2013 - Wiley Online Library
Over the past decade, the most significant, conceptual advances in the field of fluorination
were enabled most prominently by organo‐and transition‐metal catalysis. The most …

Chemistry for Positron Emission Tomography: Recent Advances in 11C‐, 18F‐, 13N‐, and 15O‐Labeling Reactions

X Deng, J Rong, L Wang, N Vasdev… - Angewandte Chemie …, 2019 - Wiley Online Library
Positron emission tomography (PET) is a molecular imaging technology that provides
quantitative information about function and metabolism in biological processes in vivo for …

Modern carbon–fluorine bond forming reactions for aryl fluoride synthesis

MG Campbell, T Ritter - Chemical Reviews, 2015 - ACS Publications
In recent years, there has been a dramatic increase in available methods for the installation
of fluorine and fluorine-containing functional groups in organic molecules, 1− 4 and the …

Fluorine-18 radiochemistry, labeling strategies and synthetic routes

O Jacobson, DO Kiesewetter, X Chen - Bioconjugate chemistry, 2015 - ACS Publications
Fluorine-18 is the most frequently used radioisotope in positron emission tomography (PET)
radiopharmaceuticals in both clinical and preclinical research. Its physical and nuclear …