Clinical application of mesenchymal stem cell in regenerative medicine: a narrative review

R Margiana, A Markov, AO Zekiy, MU Hamza… - Stem Cell Research & …, 2022 - Springer
The multipotency property of mesenchymal stem cells (MSCs) has attained worldwide
consideration because of their immense potential for immunomodulation and their …

Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Immunomodulation by mesenchymal stem cells (MSCs): mechanisms of action of living, apoptotic, and dead MSCs

ARR Weiss, MH Dahlke - Frontiers in immunology, 2019 - frontiersin.org
Expectations on mesenchymal stem cell (MSC) treatment are high, especially in the fields of
sepsis, transplant medicine, and autoimmune diseases. Various pre-clinical studies have …

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation

A Galleu, Y Riffo-Vasquez, C Trento, C Lomas… - Science translational …, 2017 - science.org
The immunosuppressive activity of mesenchymal stromal cells (MSCs) is well documented.
However, the therapeutic benefit is completely unpredictable, thus raising concerns about …

Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications

Y Huang, Q Wu, PKH Tam - International Journal of Molecular Sciences, 2022 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells with the capacity of self-renewal,
homing, and low immunogenicity. These distinct biological characteristics have already …

Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells

SFH de Witte, F Luk, JM Sierra Parraga, M Gargesha… - stem cells, 2018 - academic.oup.com
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential
immunotherapy. MSC are usually administered via intravenous infusion, after which they are …

Fracture healing: mechanisms and interventions

TA Einhorn, LC Gerstenfeld - Nature Reviews Rheumatology, 2015 - nature.com
Fractures are the most common large-organ, traumatic injuries to humans. The repair of
bone fractures is a postnatal regenerative process that recapitulates many of the ontological …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

[HTML][HTML] Mesenchymal stromal cells: sensors and switchers of inflammation

ME Bernardo, WE Fibbe - Cell stem cell, 2013 - cell.com
In addition to their stem/progenitor properties, mesenchymal stromal cells (MSCs) possess
broad immunoregulatory properties that are being investigated for potential clinical …

Toward a better regeneration through implant‐mediated immunomodulation: harnessing the immune responses

B Zhang, Y Su, J Zhou, Y Zheng, D Zhu - Advanced science, 2021 - Wiley Online Library
Tissue repair/regeneration, after implantation or injury, involves comprehensive
physiological processes wherein immune responses play a crucial role to enable tissue …