There have been significant advances in our understanding of human autoimmunity that
have led to improvements in classification and diagnosis and, most importantly, research …

MicroRNAs (miRNAs) are small, single-stranded, endogenous non-coding RNAs that
repress the expression of target genes via post-transcriptional mechanisms. Due to their …

Infection caused by SARS-CoV-2 can result in severe respiratory complications and death.
Patients with a compromised immune system are expected to be more susceptible to a …

One of the major disappointments in human autoimmunity has been the relative failure on
genome-wide association studies to provide “smoking genetic guns” that would explain the …

Objective Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease with
limited reliable diagnostic biomarkers. We investigated whether gene methylation could …

Objectives Increasing evidence suggests an epigenetic contribution to the pathogenesis of
autoimmune diseases, including primary Sjögren's Syndrome (pSS). The aim of this study …

Methylation of cytosine residues in DNA, the best studied epigenetic modification, is
associated with gene transcription and nuclear organization, and ultimately the function of a …

Objectives To identify novel DNA methylation sites significant for rheumatoid arthritis (RA)
and comprehensively understand their underlying pathological mechanism. Methods We …

Background Recent achievement in genetics and epigenetics has led to the exploration of
the pathogenesis of systemic lupus erythematosus (SLE). Identification of differentially …

Autoimmunity and chronic inflammation recognize numerous shared factors and, as a result,
the resulting diseases frequently coexist in the same patients or respond to the same …