Mitochondria as playmakers of apoptosis, autophagy and senescence

M Abate, A Festa, M Falco, A Lombardi, A Luce… - Seminars in cell & …, 2020 - Elsevier
Mitochondria are the key energy-producing organelles and cellular source of reactive
species. They are responsible for managing cell life and death by a balanced homeostasis …

[HTML][HTML] Mitochondrial channels: ion fluxes and more

I Szabo, M Zoratti - Physiological reviews, 2014 - journals.physiology.org
The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

[HTML][HTML] Curcumin combined with photodynamic therapy, promising therapies for the treatment of cancer

L Xie, X Ji, Q Zhang, Y Wei - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Curcumin, a phytochemical derived from the rhizome of turmeric (Curcuma longa L.), has a
broad group of substances with antibacterial, anti-inflammatory, anti-oxidant, anticancer …

The causes of cancer revisited:“mitochondrial malignancy” and ROS-induced oncogenic transformation–why mitochondria are targets for cancer therapy

SJ Ralph, S Rodríguez-Enríquez, J Neuzil… - Molecular aspects of …, 2010 - Elsevier
The role of oncoproteins and tumor suppressor proteins in promoting the malignant
transformation of mammalian cells by affecting properties such as proliferative signalling …

Application prospects of triphenylphosphine-based mitochondria-targeted cancer therapy

X Cheng, D Feng, J Lv, X Cui, Y Wang, Q Wang… - Cancers, 2023 - mdpi.com
Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …

Natural agents targeting mitochondria in cancer

S Mani, G Swargiary, KK Singh - International journal of molecular …, 2020 - mdpi.com
Mitochondria are the key energy provider to highly proliferating cancer cells, and are
subsequently considered one of the critical targets in cancer therapeutics. Several …

Phenolic compounds cannabidiol, curcumin and quercetin cause mitochondrial dysfunction and suppress acute lymphoblastic leukemia cells

M Olivas-Aguirre, L Torres-López, I Pottosin… - International Journal of …, 2020 - mdpi.com
Anticancer activity of different phenols is documented, but underlying mechanisms remain
elusive. Recently, we have shown that cannabidiol kills the cells of acute lymphoblastic …

Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger

SJ Ralph, S Rodríguez-Enríquez, J Neuzil… - Molecular aspects of …, 2010 - Elsevier
Mitochondria are emerging as idealized targets for anti-cancer drugs. One reason for this is
that although these organelles are inherent to all cells, drugs are being developed that …

Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but …

SJ Ralph, R Moreno-Sánchez, J Neuzil… - Pharmaceutical …, 2011 - Springer
Succinate: quinone reductase (SQR) of Complex II, occupying a unique central point in the
mitochondrial respiratory system as a major source of electrons driving reactive oxygen …

Current appraises of therapeutic applications of nanocurcumin: A novel drug delivery approach for biomaterials in dentistry

RA Bapat, SV Bedia, AS Bedia, HJ Yang… - Environmental …, 2023 - Elsevier
Curcumin is a natural herb and polyphenol that is obtained from the medicinal plant
Curcuma longa. It's anti-bacterial, anti-inflammatory, anti-cancer, anti-mutagenic, antioxidant …