Dual-specificity tyrosine phosphorylation-regulated kinases (DYRK1A, 1B, 2-4) and cdc2-
like kinases (CLK1-4) belong to the CMGC group of serine/threonine kinases. These protein …

According to the World Health Organization (WHO), 422 million people are suffering from
diabetes worldwide. Current diabetes therapies are focused on optimizing blood glucose …

Resistance to regeneration of insulin-producing pancreatic β cells is a fundamental
challenge for type 1 and type 2 diabetes. Recently, small molecule inhibitors of the kinase …

Dual-specificity, tyrosine phosphorylation-regulated kinases (DYRKs) and cdc2-like kinases
(CLKs) recently attracted attention due to their central involvement in various pathologies …

A quantitative deficiency of normally functioning insulin-producing pancreatic beta cells is a
major contributor to all common forms of diabetes. This is the underlying premise for …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

Both tumour suppressive and oncogenic functions have been reported for dual-specificity
tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed …

ABSTRACT RNA processing plays a key role in gene expression, allowing for increased
protein diversity and functional complexity. Consequently, modulating RNA processing can …

Background: DYRK1a (dual-specificity tyrosine phosphorylation-regulated kinase 1a)
contributes to the control of cycling cells, including cardiomyocytes. However, the effects of …

Decreased number and function of beta cells are a key aspect of diabetes mellitus
(diabetes), a disease that remains an onerous global health problem. Means of restoring …