Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …

Neutrophils are best known for their critical role in host defense, for which they utilize
multiple innate immune mechanisms, including microbe-associated pattern recognition …

Antibody-dependent cellular cytotoxicity (ADCC) is a major mechanism of action of
therapeutic monoclonal antibodies (mAbs) such as cetuximab, rituximab and trastuzumab …

In the last decade several therapeutic antibodies have been Federal Drug Administration
(FDA) and European Medicines Agency (EMEA) approved. Although their mechanisms of …

Immunoglobulin (Ig) G1 antibodies stimulate antibody-dependent cell-mediated cytotoxicity
(ADCC). Cetuximab, an IgG1 isotype monoclonal antibody, is a standard-of-care treatment …

Ab-dependent cellular cytotoxicity (ADCC) is usually considered an important mechanism of
action for immunotherapy with human IgG1 but not IgG2 Abs. The epidermal growth factor …

The anti-CD20 monoclonal antibody (mAb) rituximab has been used successfully for
lymphoma therapy for more than 10 years. Although several direct mechanisms by which …

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

The biological activities of human IgG antibodies predominantly rely on a family of receptors
for the Fc portion of IgG, FcγRs: FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, FcγRIIIA, FcγRIIIB, FcRL5 …

Monoclonal antibodies (mAb) are emerging as one of the major class of therapeutic agents
in the treatment of many human diseases, in particular in cancer and immunological …