New drug discovery has been acknowledged as a complicated, expensive, time-consuming,
and challenging project. It has been estimated that around 12 years and 2.7 billion USD, on …

Rational drug design implies usage of molecular modeling techniques such as
pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to …

Chrysin has been shown to exert several beneficial pharmacological activities. Chrysin has
anti-cancer, anti-viral, anti-diabetic, neuroprotective, cardioprotective, hepatoprotective, and …

Pharmacological profile of phytochemicals has attracted much attention to their use in
disease therapy. Since cancer is a major problem for public health with high mortality and …

As a multifactorial disease, treatment of cancer depends on understanding unique
mechanisms involved in its progression. The cancer stem cells (CSCs) are responsible for …

Epidermal growth factor receptor (EGFR) tyrosine kinases are overexpressed in several
human cancers and could serve as a promising anti-cancer drug target. With this in view, the …

Flavonoids, a class of polyphenolic secondary metabolites, are present in fruits, vegetables,
beverages such as wine and tea abundantly. Flavonoids exhibit a diverse array of …

In this study, novel self-assembled carbazole-thiooctanoic acid nanoparticles (CTNs) were
synthesized from amino carbazole (a mutagen) and thiooctanoic acid (an antioxidant). The …

Abstract Epidermal Growth Factor Receptor (EGFR) is a promising drug target for the
discovery of cancer chemotherapeutics. EGFR tyrosine kinase inhibitors become resistant …

Epidermal Growth Factor Receptor (EGFR), a type-I transmembrane protein with intrinsic
tyrosine kinase activity, is activated by peptide growth factors such as EGF, epigen …