The 'mitochondrial contact site and cristae organising system'(MICOS) in health and human disease

MJ Eramo, V Lisnyak, LE Formosa… - The Journal of …, 2020 - academic.oup.com
The 'mitochondrial contact site and cristae organising system'(MICOS) is an essential protein
complex that promotes the formation, maintenance and stability of mitochondrial cristae. As …

Golgi complex: a signaling hub in cancer

D Spano, A Colanzi - Cells, 2022 - mdpi.com
The Golgi Complex is the central hub in the endomembrane system and serves not only as a
biosynthetic and processing center but also as a trafficking and sorting station for …

Multi-omics and experimental analysis unveil theragnostic value and immunological roles of inner membrane mitochondrial protein (IMMT) in breast cancer

HY Lin, HJ Wu, PY Chu - Journal of Translational Medicine, 2023 - Springer
Background The inner membrane mitochondrial protein (IMMT) is a central unit of the
mitochondrial contact site and cristae organizing system (MICOS). While researchers …

High-throughput proteomics of breast cancer subtypes: Biological characterization and multiple candidate biomarker panels to patients' stratification

ALK Azevedo, THB Gomig, M Batista, FK Marchini… - Journal of …, 2023 - Elsevier
Background and aims The actual classification of breast tumors in subtypes represents an
attempt to stratify patients into clinically cohesive groups, nevertheless, clinicians still lack …

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

S Khawaled, G Nigita, R Distefano, S Oster… - Signal transduction and …, 2020 - nature.com
Tumor progression and metastasis are the major causes of death among cancer associated
mortality. Metastatic cells acquire features of migration and invasion and usually undergo …

SCAMP3 regulates EGFR and promotes proliferation and migration of triple-negative breast cancer cells through the modulation of AKT, ERK, and STAT3 signaling …

A Acevedo-Díaz, BM Morales-Cabán… - Cancers, 2022 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC) cases constitute~ 15% of breast
cancer tumors. This subtype is characterized by the lack of hormone receptors, estrogen and …

Adaptive sparse multi-block PLS discriminant analysis: an integrative method for identifying key biomarkers from multi-omics data

R Zhang, S Datta - Genes, 2023 - mdpi.com
With the growing use of high-throughput technologies, multi-omics data containing various
types of high-dimensional omics data is increasingly being generated to explore the …

Accumulation of amyloid beta (Aβ) and amyloid precursor protein (APP) in tumors formed by a mouse xenograft model of inflammatory breast cancer

A Zayas‐Santiago, MM Martínez‐Montemayor… - FEBS Open …, 2022 - Wiley Online Library
Accumulation of amyloid in breast cancer is a well‐known phenomenon, but only
immunoglobulin light‐chain amyloidosis (AL) or transthyretin (TTR) amyloid had been …

Metadherin Regulates Inflammatory Breast Cancer Invasion and Metastasis

G Ortiz-Soto, NS Babilonia-Díaz… - International Journal of …, 2023 - mdpi.com
Inflammatory breast cancer (IBC) is one of the most lethal subtypes of breast cancer (BC),
accounting for approximately 1–5% of all cases of BC. Challenges in IBC include accurate …

Proteomic analysis of amniotic fluid proteins for predicting the outcome of emergency cerclage in women with cervical insufficiency

JH Lee, JE Lee, JW Choi, MH Han, SY Seong… - Reproductive …, 2020 - Springer
We aimed to identify novel biomarkers in amniotic fluid (AF) that predict the outcome of
emergency cerclage in women with cervical insufficiency. This retrospective cohort study …