Organismal ageing is accompanied by progressive loss of cellular function and systemic
deterioration of multiple tissues, leading to impaired function and increased vulnerability to …

Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …

For dairy cattle, the first several weeks of lactation represent the highest-risk period in their
lives after their own neonatal period. Although more than 50% of cows during this period are …

Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

Ferroptosis is a recently described form of regulated cell death characterized by intracellular
iron accumulation and severe lipid peroxidation due to an impaired cysteine‐glutathione …

Neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD) and Parkinson's
disease (PD) are a heterogeneous group of disorders characterized by progressive …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

Oxidative damage is related to aging and a wide range of human disorders. Mitochondria
are in large part responsible for free radical production and they are also main targets of the …

Cells have the ability to adapt to stressful environments as a part of their evolution. Physical
exercise induces an increase of a demand for energy that must be met by mitochondria as …