Albumin-hitchhiking: fostering the pharmacokinetics and anticancer therapeutics

P Famta, S Shah, N Jain, DA Srinivasarao… - Journal of Controlled …, 2023 - Elsevier
Nanotherapeutics demonstrate poor accumulation in the tumor microenvironment due to
poor extravasation and penetration into the tumor. Therapeutics such as oligonucleotides …

Circulating miRNAs in breast cancer diagnosis and prognosis

B Cardinali, R Tasso, P Piccioli, MC Ciferri, R Quarto… - Cancers, 2022 - mdpi.com
Simple Summary In the era of precision medicine, new tools for better management of breast
cancer patients are still needed. From this perspective, circulating microRNA (miRNA), a …

Highly effective detection of exosomal miRNAs in plasma using liposome-mediated transfection CRISPR/Cas13a

J Zhang, M Guan, C Ma, Y Liu, M Lv, Z Zhang… - ACS …, 2023 - ACS Publications
Exosomal miRNAs play a critical role in cancer biology and could be potential biomarkers
for cancer diagnosis. However, due to the low abundance of miRNAs in the exosomes …

MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms

LH Chi, RSN Cross, RP Redvers, M Davis… - Oncogenesis, 2022 - nature.com
MiR-21 was identified as a gene whose expression correlated with the extent of metastasis
of murine mammary tumours. Since miR-21 is recognised as being associated with poor …

lncRNA GAS5 sensitizes breast cancer cells to ionizing radiation by inhibiting DNA repair

Y Ma, L Yu, W Yan, L Qiu, J Zhang… - BioMed research …, 2022 - Wiley Online Library
Radioresistance of breast cancer is a major reason for therapeutic failure and limits further
increases in the dose of radiation due to severe adverse effects. Recently, long noncoding …

Evaluation of miRNA-21-5p and miRNA-10b-5p levels in serum-derived exosomes of breast cancer patients in different grades

A Asadirad, A Khodadadi, A Talaiezadeh… - Molecular and cellular …, 2022 - Elsevier
Background & objectives Tumor cells have various effects and dominance over other
healthy cells. Cancer cells alter the cell program in healthy cells by secreting exosomes …

MiR-21 in the cancers of the digestive system and its potential role as a diagnostic, predictive, and therapeutic biomarker

HT Nguyen, SEO Kacimi, TL Nguyen, KH Suman… - Biology, 2021 - mdpi.com
Simple Summary MicroRNAs are small, non-coding RNA molecules that can regulate the
expression of various cancer-related genes and thereby contribute to tumorigenesis and …

Addressing the clinical feasibility of adopting circulating miRNA for breast cancer detection, monitoring and management with artificial intelligence and machine …

L Ling, AF Aldoghachi, ZX Chong, WY Ho… - International journal of …, 2022 - mdpi.com
Detecting breast cancer (BC) at the initial stages of progression has always been regarded
as a lifesaving intervention. With modern technology, extensive studies have unraveled the …

In situ detection of exosomal RNAs for cancer diagnosis

Z Sun, Y Wu, F Gao, H Li, C Wang, L Du, L Dong… - Acta Biomaterialia, 2023 - Elsevier
Exosomes are considered as biomarkers reflecting the physiological state of the human
body. Studies have revealed that the expression levels of specific exosomal RNAs are …

The impact of microRNAs on the resistance of breast cancer subtypes to chemotherapy

A Ebrahimi, PB Shahrebabaki, H Fouladi… - … -Research and Practice, 2023 - Elsevier
Breast cancer (BC) formation is primarily influenced by genetics, epigenetics and
environmental factors. Aberrant Genetics and epigenetics leads to a condition known as …