There are numerous biochemical and biological processes that occur after death that may
have a significant influence on post-mortem drug concentrations. These processes may …

A total of twenty-five novel carboxylic acid, methylester, methylamide or cyano nonsteroidal
anti-inflammatory drug (NSAID) derivatives incorporating Se in the chemical form of …

The gastrointestinal (GI) stability of three flavonoids, dihydromyricetin (DMY), myricetin
(MYR), and myricitrin (MYT), was examined in simulated physiological fluids. Several factors …

Carvacrol (CAR), a natural monoterpene particularly abundant in plants belonging to the
Lamiaceae family, has recently attracted much attention for its many biological properties …

Stability is one of the most important properties of drug candidates. Instable compounds can
lead to false positive high‐throughput screening (HTS) hits, incorrect bioassay results …

Clostridioides difficile is the leading cause of nosocomial infections and a worldwide urgent
public health threat. Without doubt, there is an urgent need for new effective anticlostridial …

The aim of the current study is to preserve the emulsomal vesicles against the harsh
condition of gastrointestinal tract (GIT), after oral administration, employing tripolyphosphate …

Glioblastoma is one of the most aggressive malignant primary brain cancer in adults. To
date, surgery, radiotherapy and current pharmacological treatments are not sufficient to …

Herein we describe the discovery of the novel CRTh2 antagonist 2-(2-(1-naphthoyl)-8-fluoro-
3, 4-dihydro-1 H-pyrido [4, 3-b] indol-5 (2 H)-yl) acetic acid 28 (setipiprant/ACT-129968), a …

To date, drugs that hit a single target are inadequate for the treatment of neurodegenerative
diseases, such as Alzheimer's or Parkinson's diseases. The development of multitarget …