The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair

B Vollmar, MD Menger - Physiological reviews, 2009 - journals.physiology.org
The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

New insights in mechanisms and therapeutics for short-and long-term impacts of hepatic ischemia reperfusion injury post liver transplantation

H Liu, K Man - International journal of molecular sciences, 2021 - mdpi.com
Liver transplantation has been identified as the most effective treatment for patients with end-
stage liver diseases. However, hepatic ischemia reperfusion injury (IRI) is associated with …

Small-for-size syndrome in liver transplantation: definition, pathophysiology and management

Y Masuda, K Yoshizawa, Y Ohno, A Mita… - … & Pancreatic Diseases …, 2020 - Elsevier
Background Since the first success in an adult patient, living donor liver transplantation
(LDLT) has become an universally used procedure. Small-for-size syndrome (SFSS) is a …

Pathophysiologic observations and histopathologic recognition of the portal hyperperfusion or small-for-size syndrome

AJ Demetris, DM Kelly, B Eghtesad… - The American journal …, 2006 - journals.lww.com
In an attempt to more completely define the histopathologic features of the portal vein
hyperperfusion or small-for-size syndrome (PHP/SFSS), we strictly identified 5 PHP/SFSS …

miR-146a ameliorates liver ischemia/reperfusion injury by suppressing IRAK1 and TRAF6

W Jiang, L Kong, Q Ni, Y Lu, W Ding, G Liu, L Pu… - PLoS …, 2014 - journals.plos.org
A critical role of the Toll-like receptor (TLR) and its downstream molecules, including IL-1
receptor-associated kinase 1 (IRAK1) and tumor necrosis factor receptor–associated factor 6 …

[PDF][PDF] Ischemia‐reperfusion of small liver remnant promotes liver tumor growth and metastases—Activation of cell invasion and migration pathways

K Man, KT Ng, CM Lo, JW Ho, BS Sun… - Liver …, 2007 - Wiley Online Library
Elucidating the mechanism of liver tumor growth and metastasis after hepatic ischemia‐
reperfusion (I/R) injury of a small liver remnant will lay the foundation for the development of …

Mesenchymal stem cells over-expressing hepatocyte growth factor improve small-for-size liver grafts regeneration

Y Yu, AH Yao, N Chen, LY Pu, Y Fan, L Lv, BC Sun… - Molecular Therapy, 2007 - cell.com
Ischemia-reperfusion (I/R) associated with small-for-size liver transplantation (SFSLT)
impairs liver graft regeneration. Mesenchymal stem cells (MSCs) have the capability, under …

Small for Size and Flow (SFSF) syndrome: An alternative description for posthepatectomy liver failure

M Golriz, A Majlesara, S El Sakka, M Ashrafi… - Clinics and research in …, 2016 - Elsevier
Summary Small for Size Syndrome (SFSS) syndrome is a recognizable clinical syndrome
occurring in the presence of a reduced mass of liver, which is insufficient to maintain normal …

Effects of prophylactic splenic artery modulation on portal overperfusion and liver regeneration in small-for-size graft

Y Umeda, T Yagi, H Sadamori, H Matsukawa… - …, 2008 - journals.lww.com
Background. The small-for-size (SFS) syndrome is caused by excessive portal inflow into a
small-sized liver graft. Various approaches for portal decompression have been used, but …

[PDF][PDF] Attenuation of acute phase shear stress by somatostatin improves small‐for‐size liver graft survival

X Xu, K Man, SS Zheng, TB Liang, TK Lee… - Liver …, 2006 - Wiley Online Library
The major concern of living donor liver transplantation is small‐for‐size graft injury at the
early phase after transplantation. Novel therapeutic strategies should be developed. To …