A long-term aim of the life sciences is to understand how organismal shape is encoded by
the genome. An important challenge is to identify mechanistic links between the genes that …

The extracellular signal-regulated kinase (ERK) pathway leads to activation of the effector
molecule ERK, which controls downstream responses by phosphorylating a variety of …

Transient increases in mitochondrially-derived reactive oxygen species (ROS) activate an
adaptive stress response to promote longevity. Nicotinamide adenine dinucleotide …

Human cancer is caused by the interplay of mutations in oncogenes and tumor suppressor
genes and inherited variations in cancer susceptibility genes. While many of the tumor …

Cell invasion is an initiating event during tumor cell metastasis and an essential process
during development. A screen of C. elegans orthologs of genes overexpressed in invasive …

Caenorhabditis elegans larvae display developmental plasticity in response to
environmental conditions: in adverse conditions, second-stage larvae enter a reversible …

EGF, emitted by the Anchor Cell, patterns six equipotent C. elegans vulval precursor cells to
assume a precise array of three cell fates with high fidelity. A group of core and modulatory …

The Caenorhabditis elegans hermaphrodite vulva is one of the best studied models for
signal transduction and cell fate determination during organogenesis. Systematic forward …

Ezrin is a scaffolding protein that is involved in oncogenesis by linking cytoskeletal and
membrane proteins. Ezrin interacts with epidermal growth factor receptor (EGFR) in the cell …

During Caenorhabditis elegans vulval development, the uterine anchor cell (AC) first
secretes an epidermal growth factor (EGF) to specify the vulval cell fates and then invades …