Encapsulation of active pharmaceutical ingredients in lipid micro/nanoparticles for oral administration by spray-cooling

CS Favaro-Trindade, FE de Matos Junior, PK Okuro… - Pharmaceutics, 2021 - mdpi.com
Nanoencapsulation via spray cooling (also known as spray chilling and spray congealing)
has been used with the aim to improve the functionality, solubility, and protection of drugs; …

Inulin and its application in drug delivery

F Afinjuomo, S Abdella, SH Youssef, Y Song, S Garg - Pharmaceuticals, 2021 - mdpi.com
Inulin's unique and flexible structure, stabilization/protective effects, and organ targeting
ability make it an excellent drug delivery carrier compared to other biodegradable …

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14

A Levit, S Nowak, M Peters, A Wiener… - The FASEB …, 2014 - Wiley Online Library
Bitter taste receptors (TAS2Rs) mediate aversive response to toxic food, which is often bitter.
These G‐protein‐coupled receptors are also expressed in extraoral tissues, and emerge as …

Prodrugs Design Based on Inter‐and Intramolecular Chemical Processes

R Karaman - Chemical biology & drug design, 2013 - Wiley Online Library
This review provides the reader a concise overview of the majority of prodrug approaches
with the emphasis on the modern approaches to prodrug design. The chemical approach …

Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios

A Di Pizio, A Levit, M Slutzki, M Behrens… - Methods in cell …, 2016 - Elsevier
G protein-coupled receptors (GPCRs) are seven transmembrane (TM) proteins that play a
key role in human physiology. The GPCR superfamily comprises about 800 members …

BitterSweetForest: a random forest based binary classifier to predict bitterness and sweetness of chemical compounds

P Banerjee, R Preissner - Frontiers in chemistry, 2018 - frontiersin.org
Taste of a chemical compound present in food stimulates us to take in nutrients and avoid
poisons. However, the perception of taste greatly depends on the genetic as well as …

Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists

R Karaman, S Nowak, A Di Pizio… - Chemical biology & …, 2016 - Wiley Online Library
Sensing potentially harmful bitter substances in the oral cavity is achieved by a group of˜ 25
receptors, named TAS 2Rs, which are expressed in specialized sensory cells and recognize …

The future of prodrugs–design by quantum mechanics methods

R Karaman, B Fattash, A Qtait - Expert opinion on drug delivery, 2013 - Taylor & Francis
Introduction: The revolution in computational chemistry greatly impacted the drug design
and delivery fields, in general, and recently the utilization of the prodrug approach in …

Masking the bitter taste of injectable lidocaine HCl formulation for dental procedures

Y Wei, MP Nedley, SB Bhaduri, X Bredzinski… - Aaps Pharmscitech, 2015 - Springer
Several attempts have been made to mask the bitter taste of oral formulations, but none
have been made for injectable formulations. This study aims to mask the bitter taste of dental …

Prodrugs: Harnessing chemical modifications for improved therapeutics

R Kumar, C Kaur, K Kaur, N Khurana… - Journal of Drug Delivery …, 2023 - Elsevier
A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …