Phosphorylation offers a dynamic way to regulate protein activity and subcellular
localization, which is achieved through its reversibility and fast kinetics. Adding or removing …

In response to extracellular stimuli, the Raf/MEK/extracellular signal-regulated kinase (ERK)
pathway regulates diverse cellular processes. While mainly known as a mitogenic signaling …

It has recently been proposed by Gunasakaran et al. that allostery may be an intrinsic
property of all proteins. Here, we develop a computational method that can determine and …

Unique characteristics distinguish extracellular signal-regulated kinases (Erks) from other
eukaryotic protein kinases (ePKs). Unlike most ePKs, Erks do not autoactivate and they …

The complexity of cancer and the vast amount of experimental data available have made
computer-aided approaches necessary. Biomolecular modelling techniques are becoming …

Conformational selection by small molecules expands inhibitory possibilities for protein
kinases. Nuclear magnetic resonance (NMR) measurements of the mitogen-activated …

Protein kinases are crucial to coordinate cellular decisions and therefore their activities are
strictly regulated. Previously we used ancestral reconstruction to determine how CMGC …

ABSTRACT A fast and approximate method of generating allosteric communication
landscapes in proteins is presented by using Schreiber's entropy transfer concept in …

Previous studies of the protein kinase, ERK2, using NMR and hydrogen-exchange
measurements have shown changes in dynamics accompanying its activation by …

Allostery is a key biological control mechanism, and dynamic information flow provides a
perspective to describe allosteric interactions in causal relationships. Here, as a novel …