Transcription factors and 3D genome conformation in cell-fate decisions
How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …
response to environmental cues results in the activation of transcription factors that …
Heterochromatin: guardian of the genome
A Janssen, SU Colmenares… - Annual review of cell and …, 2018 - annualreviews.org
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
essential for the maintenance of genome stability. Highly concentrated at pericentromeric …
Regulation of genome organization and gene expression by nuclear mechanotransduction
C Uhler, GV Shivashankar - Nature reviews Molecular cell biology, 2017 - nature.com
It is well established that cells sense chemical signals from their local microenvironment and
transduce them to the nucleus to regulate gene expression programmes. Although a number …
transduce them to the nucleus to regulate gene expression programmes. Although a number …
Phase separation of RNA-binding protein promotes polymerase binding and transcription
An RNA-involved phase-separation model has been proposed for transcription control.
However, the molecular links that connect RNA to the transcription machinery remain …
However, the molecular links that connect RNA to the transcription machinery remain …
[HTML][HTML] Chromatin fibers are formed by heterogeneous groups of nucleosomes in vivo
Nucleosomes help structure chromosomes by compacting DNA into fibers. To gain insight
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …
into how nucleosomes are arranged in vivo, we combined quantitative super-resolution …
Multifactorial profiling of epigenetic landscapes at single-cell resolution using MulTI-Tag
MP Meers, G Llagas, DH Janssens, CA Codomo… - Nature …, 2023 - nature.com
Chromatin profiling at locus resolution uncovers gene regulatory features that define cell
types and developmental trajectories, but it remains challenging to map and compare …
types and developmental trajectories, but it remains challenging to map and compare …
Transcription factors orchestrate dynamic interplay between genome topology and gene regulation during cell reprogramming
Chromosomal architecture is known to influence gene expression, yet its role in controlling
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …
cell fate remains poorly understood. Reprogramming of somatic cells into pluripotent stem …
A decade of exploring the cancer epigenome—biological and translational implications
The past decade has highlighted the central role of epigenetic processes in cancer
causation, progression and treatment. Next-generation sequencing is providing a window …
causation, progression and treatment. Next-generation sequencing is providing a window …
Mechanosensing by the nucleus: From pathways to scaling relationships
The nucleus is linked mechanically to the extracellular matrix via multiple polymers that
transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some …
transmit forces to the nuclear envelope and into the nuclear interior. Here, we review some …
MCM2 promotes symmetric inheritance of modified histones during DNA replication
During genome replication, parental histones are recycled to newly replicated DNA with
their posttranslational modifications (PTMs). Whether sister chromatids inherit modified …
their posttranslational modifications (PTMs). Whether sister chromatids inherit modified …