The preproglucagon gene (Gcg) is expressed by specific enteroendocrine cells (L-cells) of
the intestinal mucosa, pancreatic islet α-cells, and a discrete set of neurons within the …

The gastrointestinal tract presents the largest and most vulnerable surface to the outside
world. Simultaneously, it must be accessible and permeable to nutrients and must defend …

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and
the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen …

Bile acids are well-recognized stimuli of glucagon-like peptide-1 (GLP-1) secretion. This
action has been attributed to activation of the G protein–coupled bile acid receptor GPBAR1 …

Recent progress in unravelling the nutrient-sensing mechanisms in the taste buds of the
tongue has triggered studies on the existence and role of chemosensory cells in the gut …

Sweet taste receptors are a heterodimer composed of taste type 1 receptor 2 (T1R2) and
taste type 1 receptor 3 (T1R3) that senses sweet taste in taste buds. More recently, sweet …

The enteroendocrine system is the primary sensor of ingested nutrients and is responsible
for secreting an array of gut hormones, which modulate multiple physiological responses …

The release of gut hormones involved in the control of food intake is dependent on the acute
nutritional status of the body, suggesting that chemosensory mechanisms are involved in the …

Gut endocrine cells are generally thought to have distinct localization and secretory
products. Recent studies suggested that the cells are highly related and have potential to …

Taste receptors were first identified on the tongue, where they initiate a signaling pathway
that communicates information to the brain about the nutrient content or potential toxicity of …