Although plasmid-mediated quinolone resistance (PMQR) was thought not to exist before its
discovery in 1998, the past decade has seen an explosion of research characterizing this …

In this review those fluorinated compounds which have found a role as anti-cancer agents
are summarized. The emphasis is to highlight the important drugs but also to highlight the …

This paper on the fluoroquinolone resistance epidemiology stratifies the data according to
the different prescription patterns by either primary or tertiary caregivers and by indication …

The ffuoroquinolones are broad-spectrum antibacterial agents that are becoming
increasingly popular as bacterial resistance erodes the effectiveness of other agents …

The quinolone class of antimicrobial agents has generated considerable interest since its
discovery> 40 years ago. Substantial progress has been made in our understanding of the …

In 1998, the first plasmid-mediated gene involved in quinolone resistance (currently named
qnrA1) was reported. Extra qnr-like plasmid-mediated genes (qnrB, qnrS, qnrC, qnrD) and …

The mutant selection window is an antimicrobial concentration range extending from the
minimal concentration required to block the growth of wild-type bacteria up to that required …

Quinolones are one of the largest classes of antimicrobial agents used worldwide. This
review considers the quinolones that are available currently and used widely in Europe …

Studies with fluoroquinolones have led to a general method for restricting the selection of
antibiotic-resistant mutants. The strategy is based on the use of antibiotic concentrations that …

Increasing development costs and higher failure rate in clinical trials has reduced the
repertoire of newer drugs in the market for clinical use. The most appropriate approach to …