Poly (N-isopropylacrylamide)-based thermoresponsive surfaces provide new types of biomedical applications

K Nagase, M Yamato, H Kanazawa, T Okano - Biomaterials, 2018 - Elsevier
Thermoresponsive surfaces, prepared by grafting of poly (N-isopropylacrylamide)(PIPAAm)
or its copolymers, have been investigated for biomedical applications. Thermoresponsive …

Smart polymers: Physical forms and bioengineering applications

A Kumar, A Srivastava, IY Galaev… - Progress in polymer …, 2007 - Elsevier
Smart polymers (SP) have become one important class of polymers and their applications
have been increasing significantly. Last two to three decades have witnessed explosive …

Stimuli-responsive surfaces for bio-applications

PM Mendes - Chemical Society Reviews, 2008 - pubs.rsc.org
The development of surfaces that have switchable properties, also known as smart surfaces,
have been actively pursued in the past few years. The recent surge of interest in these …

Stimuli-responsive interfaces and systems for the control of protein–surface and cell–surface interactions

MA Cole, NH Voelcker, H Thissen, HJ Griesser - Biomaterials, 2009 - Elsevier
Real-time control over and reversibility of biomolecule–surface interactions at interfaces is
an increasingly important goal for a range of scientific fields and applications. The field of …

Temperature-responsive intelligent interfaces for biomolecular separation and cell sheet engineering

K Nagase, J Kobayashi… - Journal of the Royal …, 2009 - royalsocietypublishing.org
Temperature-responsive intelligent surfaces, prepared by the modification of an interface
with poly (N-isopropylacrylamide) and its derivatives, have been used for biomedical …

Nanostructured designs of biomedical materials: applications of cell sheet engineering to functional regenerative tissues and organs

A Kikuchi, T Okano - Journal of Controlled Release, 2005 - Elsevier
Biomaterials surface design is critical for control of cell–materials interactions. Materials
surface characteristics important to cell–materials interactions are the following:(a) …

Controlled chain length and graft density of thermoresponsive polymer brushes for optimizing cell sheet harvest

H Takahashi, M Nakayama, M Yamato… - …, 2010 - ACS Publications
Novel thermoresponsive polymer brush surfaces for harvesting cell sheet were fabricated by
the surface-initiated RAFT polymerization of N-isopropylacrylamide (IPAAm) on azoinitiator …

Temperature-responsive cell culture surfaces enable “on− off” affinity control between cell integrins and RGDS ligands

M Ebara, M Yamato, T Aoyagi, A Kikuchi… - …, 2004 - ACS Publications
In this study, specific interactions between immobilized RGDS (Arg-Gly-Asp-Ser) cell
adhesion peptides and cell integrin receptors located on cell membranes are controlled in …

Stimuli responsive materials: new avenues toward smart organic devices

R Yerushalmi, A Scherz, ME van der Boom… - Journal of Materials …, 2005 - pubs.rsc.org
“Smart” patternable polymer-based materials that can be designed from various molecular
building blocks show great potential, as they may be used in many fields, including …

Thermoresponsive-polymer-based materials for temperature-modulated bioanalysis and bioseparations

K Nagase, T Okano - Journal of Materials Chemistry B, 2016 - pubs.rsc.org
Many bioactive compounds, pharmaceutical proteins, and therapeutic cells are used in
medical treatments. Methods for the effective purification of such compounds that retain their …