Estradiol, either from peripheral or central origin, activates multiple molecular
neuroprotective and neuroreparative responses that, being mediated by estrogen receptors …

Most of the genetic variation associated with diabetes, through genome-wide association
studies, does not reside in protein-coding regions, making the identification of functional …

Background and purpose: Neurological diseases and injuries to the nervous system may
cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would …

17β-Estradiol (estradiol or E2) is a steroid hormone that has been broadly applied as a
neuroprotective therapy for a variety of neurodegenerative and cerebrovascular disorders …

Selective estrogen receptor modulators (SERMs), used for the treatment of breast cancer,
osteoporosis, and menopausal symptoms, affect the nervous system. Some SERMs trigger …

Background: Tamoxifen (TX), a selective estrogen receptor modulator, enhances glutamate
transporter (GLT-1) expression in astrocytes. Results: TX up-regulated GLT-1 expression via …

The current study was undertaken to elucidate a possible neuroprotective role of
dehydroepiandrosterone (DHEA) against the development of Alzheimer's disease in …

The number of breast cancer survivors is gradually increasing and a subset of these patients
experience long-term adverse effects of adjuvant systemic therapy, including cognitive …

Neuroprotection by estrogen in the CNS is well‐documented and comprises the intricate
regulation of cell–cell communication between neurons and supportive non‐neuronal glial …

Synthetic selective modulators of the estrogen receptors (SERMs) have shown to protect
neurons and glial cells against toxic insults. Among the most relevant beneficial effects …