Targeting the eIF4F translation initiation complex: a critical nexus for cancer development
J Pelletier, J Graff, D Ruggero, N Sonenberg - Cancer research, 2015 - AACR
Elevated protein synthesis is an important feature of many cancer cells and often arises as a
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …
consequence of increased signaling flux channeled to eukaryotic initiation factor 4F (eIF4F) …
Structure and mechanism of helicases and nucleic acid translocases
MR Singleton, MS Dillingham, DB Wigley - Annu. Rev. Biochem., 2007 - annualreviews.org
Helicases and translocases are a ubiquitous, highly diverse group of proteins that perform
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …
an extraordinary variety of functions in cells. Consequently, this review sets out to define a …
CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3
The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain
incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules …
incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules …
Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
Rocaglamide A (RocA) typifies a class of protein synthesis inhibitors that selectively kill
aneuploid tumour cells and repress translation of specific messenger RNAs,,,. RocA targets …
aneuploid tumour cells and repress translation of specific messenger RNAs,,,. RocA targets …
Initiation of translation in prokaryotes and eukaryotes
M Kozak - Gene, 1999 - Elsevier
The mechanisms whereby ribosomes engage a messenger RNA and select the start site for
translation differ between prokaryotes and eukaryotes. Initiation sites in polycistronic …
translation differ between prokaryotes and eukaryotes. Initiation sites in polycistronic …
Helicases: amino acid sequence comparisons and structure-function relationships
AE Gorbalenya, EV Koonin - Current opinion in structural biology, 1993 - Elsevier
DNA and RNA helicases are ubiquitous enzymes that mediate the nucleoside-triphosphate-
dependent unwinding of nucleic acid duplexes, a necessary step in genome replication …
dependent unwinding of nucleic acid duplexes, a necessary step in genome replication …
The DEAD-box protein family of RNA helicases
RNA helicases of the DEAD-box protein family have been shown to participate in every
aspect of RNA metabolism. They are present in most organisms where they work as RNA …
aspect of RNA metabolism. They are present in most organisms where they work as RNA …
A canine distemper virus epidemic in Serengeti lions (Panthera leo)
ME Roelke-Parker, L Munson, C Packer, R Kock… - Nature, 1996 - nature.com
CANINE distemper virus (CDV) is thought to have caused several fatal epidemics in canids
within the Serengeti–Mara ecosystem of East Africa, affecting silver-backed jackals (Canis …
within the Serengeti–Mara ecosystem of East Africa, affecting silver-backed jackals (Canis …
Identification of multiple distinct Snf2 subfamilies with conserved structural motifs
The Snf2 family of helicase-related proteins includes the catalytic subunits of ATP-
dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate …
dependent chromatin remodelling complexes found in all eukaryotes. These act to regulate …
DEAD-box proteins: the driving forces behind RNA metabolism
S Rocak, P Linder - Nature reviews Molecular cell biology, 2004 - nature.com
RNA helicases from the DEAD-box family are found in almost all organisms and have
important roles in RNA metabolism. They are associated with many processes ranging from …
important roles in RNA metabolism. They are associated with many processes ranging from …