The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

This study investigated the effect of nanoparticle size (50 and 100 nm) and surface charge
on their interaction with Caco-2 monolayers as a model of the intestinal epithelium, including …

Lysosomes are acidic cell compartments containing a large set of hydrolytic enzymes. These
lysosomal hydrolases degrade proteins, lipids, polysaccharides, and nucleic acids into their …

B cells are key components of the adaptive immune response. Their differentiation into
either specific memory B cells or antibody-secreting plasma cells is a consequence of …

Polarized cells such as epithelial cells and neurons exhibit different plasma membrane
domains with distinct protein compositions. Recent studies have shown that sorting of …

Uranium (U) is a well-known nephrotoxicant which forms precipitates in the lysosomes of
renal proximal tubular epithelial cells (PTECs) after U-exposure at a cytotoxic dose …

Compared to normal cells, cancer cells require more energy supply during proliferation and
metabolism. In living cells, in addition to mitochondria, lipid droplets are also an important …

The restrictive nature of the blood–brain barrier means that cellular machinery must be in
place to deliver macromolecules to the brain. This is achieved by transcytosis which is more …

Lysosomes are acidic compartments in mammalian cells that are primarily responsible for
the breakdown of endocytic and autophagic substrates such as membranes, proteins, and …