Many anticancer strategies rely on the promotion of apoptosis in cancer cells as a means to
shrink tumors. Crucial for apoptotic function are executioner caspases, most notably …

Micronutrition is essential for neural tube closure, and zinc deficiency is associated with
human neural tube defects. Here, we modeled zinc deficiency in mouse embryos, and used …

The rise of antimicrobial resistance (AMR) worldwide and the increasing spread of multi-
drug-resistant organisms expressing metallo-β-lactamases (MBL) require the development …

Abstract Procaspase-3-activating compound 1 (PAC-1) induces procaspase-3 activation via
zinc chelation. However, whether PAC-1 employs other mechanisms remains unknown …

PAC-1 induces the activation of procaspase-3 in vitro and in cell culture by chelation of
inhibitory labile zinc ions via its ortho-hydroxy-N-acylhydrazone moiety. First reported in …

Procaspase-activating compound 1 (PAC-1) is an o-hydroxy-N-acylhydrazone that induces
apoptosis in cancer cells by chelation of labile inhibitory zinc from procaspase-3. PAC-1 has …

Antibiotics are key drugs in modern healthcare, especially in hospitals, where multiresistant
bacteria resides and is a potential threat to human health. In the present work, a new series …

Caspase‐3 is a critical effector caspase in apoptosis cascade, and is often over‐expressed
in many cancer tissues. The first synthesized procaspase‐3 activator, PAC‐1, induces …

In vitro viability assays against a representative panel of human cancer cell lines revealed
that polyamines L1a and L5a displayed remarkable activity with IC50 values in the …

Purpose To develop more potent procaspase-3 activator, 7 novel derivatives of PAC-1 were
synthesized and evaluated. Among them, SM-1 stood out for its promising activity and good …