Arthritis is inflammation of the joints accompanied by osteochondral destruction. It can take
many forms, including osteoarthritis, rheumatoid arthritis, and psoriatic arthritis. These …

An imbalance in gene expressional events skewing chondrocyte anabolic and catabolic
pathways toward the latter causes an aberrant turnover and loss of extracellular matrix …

The pathogenesis of osteoarthritis (OA) is poorly understood, and therapeutic approaches
are limited to preventing progression of the disease. Recent studies have shown that …

Epigenetic abnormalities are part of the pathogenetic alterations involved in the
development of rheumatic disorders. In this context, the main musculoskeletal cell lineages …

Abstract Histone deacetylase 3 (HDAC3) plays a pivotal role in the repression of cartilage-
specific gene expression in human chondrocytes. The aim of this study was to determine …

Abnormal post-transcriptional modulations in inflammatory genes by microRNAs (miRNAs)
play a crucial role in human disorders including arthritis. In this study, we determined the …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

The engineering of osteochondral interfaces remains a challenge. MicroRNAs (miRs) have
emerged as significant tools to regulate the differentiation and proliferation of osteogenic …

Background Estrogen deficiency is closely related to the development of menopausal
arthritis. Estrogen replacement therapy (ERT) shows a protective effect against the …

Exosomes (EXs) are nanocarrier vesicles with 20‐50 nm dimensions. They are involved in
cell proliferation and differentiation and in protecting the integrity of materials. They can be …