Dysfunctional natural killer cells in the aftermath of cancer surgery

L Angka, ST Khan, MK Kilgour, R Xu… - International journal of …, 2017 - mdpi.com
The physiological changes that occur immediately following cancer surgeries initiate a chain
of events that ultimately result in a short pro-, followed by a prolonged anti-, inflammatory …

The prognostic value of natural killer cells and their receptors/ligands in hepatocellular carcinoma: a systematic review and meta-analysis

JS Xue, ZN Ding, GX Meng, LJ Yan, H Liu… - Frontiers in …, 2022 - frontiersin.org
Background Natural killer (NK) cells play major roles in eliminating tumor cells. Preliminary
studies have shown that NK cells and their receptors/ligands have prognostic value in …

Evaluation of prognostic efficacy of liver immune status index in predicting postoperative outcomes in hepatocellular carcinoma patients: A multi‐institutional …

Y Imaoka, M Ohira, T Kobayashi… - Journal of Hepato …, 2024 - Wiley Online Library
Background Hepatocellular carcinoma (HCC) ranks third in cancer‐related deaths globally.
Despite treatment advances, high post‐hepatectomy recurrence rates (RR), especially with …

Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis

D Matzov, M Taoka, Y Nobe, Y Yamauchi… - Nucleic acids …, 2020 - academic.oup.com
Ribosomal RNA is the central component of the ribosome, mediating its functional and
architectural properties. Here, we report the cryo-EM structure of a highly divergent …

MiR-615-5p depresses natural killer cells cytotoxicity through repressing IGF-1R in hepatocellular carcinoma patients

MA Rahmoon, RA Youness, AI Gomaa, MT Hamza… - Growth …, 2017 - Taylor & Francis
Abstract miR-615-5p was characterized by our group as a tumour suppressor. IGF-1 R
activates a downstream signalling pathway, well characterized in liver cells, however, its role …

Role of cellular, molecular and tumor microenvironment in hepatocellular carcinoma: Possible targets and future directions in the regorafenib era

S Juengpanich, W Topatana, C Lu… - … Journal of Cancer, 2020 - Wiley Online Library
Hepatocellular carcinoma (HCC) remains as one of the major causes of cancer‐related
mortality, despite the recent development of new therapeutic options. Regorafenib, an oral …

The potential for cancer immunotherapy in targeting surgery-induced natural killer cell dysfunction

M Market, KE Baxter, L Angka, MA Kennedy, RC Auer - Cancers, 2018 - mdpi.com
Natural Killer (NK) cells are granular lymphocytes of the innate immune system that are able
to recognize and kill tumor cells without undergoing clonal selection. Discovered over 40 …

The imbalance between NKG2A and NKG2D expression is involved in NK cell immunosuppression and tumor progression of patients with hepatitis B virus‐related …

L Yu, L Sun, X Liu, X Wang, H Yan, Q Pu… - Hepatology …, 2023 - Wiley Online Library
Background Immunosuppression in a tumor microenvironment is associated with enhanced
tumor progression. Natural killer group 2 (NKG2) family proteins, including inhibitory …

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches

M Yu, Z Li - Frontiers of Medicine, 2017 - Springer
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third
leading cause of cancer-related mortalities worldwide. In the last few years, treatments for …

Combining IL-10 and Oncolytic Adenovirus Demonstrates Enhanced Antitumor Efficacy Through CD8+ T Cells

D Chen, L Huang, H Zhou, Y Zhang - Frontiers in immunology, 2021 - frontiersin.org
Oncolytic viruses are of growing importance in cancer therapeutics since they combine
direct oncolytic effect and the stimulation of antitumor immunity. Emerging evidences …