Oxidative stress occurs through an imbalance between the generation of reactive oxygen
species (ROS) and the antioxidant defense mechanisms of cells. The eye is particularly …

Dry eye is a common ocular surface inflammatory disease that significantly affects quality of
life. Dysfunction of the lacrimal function unit (LFU) alters tear composition and breaks ocular …

Purpose Inflammatory molecules have been demonstrated in the tear film of patients with
severe dry eye disease (DED). However, little attention has been paid to the most frequent …

Background Proteases, protease activity and inflammatory molecules in tears have been
found to be relevant in the pathogenesis of keratoconus. We sought to determine the …

Atopic keratoconjunctivitis is a chronic noninfectious inflammatory condition and is one of
the most severe ophthalmic complications associated with atopic dermatitis. It requires …

Introduction: In vitro cell models have been used to predict drug permeation in early stages
of drug development, since they represent an easy and reproducible method, allowing the …

A healthy ocular surface environment is essential to preserve visual function, and as such
the eye has evolved a complex network of mechanisms to maintain homeostasis …

Aims The ocular surface is the very first barrier between the visual system and external
environment. It protects the eye from the exposure to various light sources that significantly …

Recalcitrant AKC may be a blinding condition. Understanding the immunopathogenesis of
atopic dermatitis and AKC has already influenced therapy and is essential to the …

Purpose: Dry eye disease (DED) is a prevalent inflammatory disorder of the lacrimal
functional unit of multifactorial origin leading to chronic ocular surface disease, impaired …