Oxidative stress is a common denominator in the pathology of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

Cocaine is a powerful stimulant of the sympathetic nervous system by inhibiting
catecholamine reuptake, stimulating central sympathetic outflow, and increasing the …

Overactivation of the sympatho-adrenergic system is an essential mechanism providing
short-term adaptation to the stressful conditions of critical illnesses. In the same way, the …

Chronic oxidative stress and oxidative damage of the cerebral microvasculature and brain
cells has become one of the most convincing theories in neurodegenerative pathology …

The heart is a target organ for oxidative stress-related injuries. Because of its very high
energetic metabolic demand, the heart has the highest rate of production of reactive oxygen …

Oxidative stress attributable to the activation of a Nox2-containing NADPH oxidase is
involved in the development of vascular diseases and in aging. However, the mechanism of …

Supraphysiologic-dose anabolic-androgenic steroid (AAS) use is associated with
physiologic, cognitive, and brain abnormalities similar to those found in people at risk for …

Role of cocaine in influencing blood–brain barrier (BBB) function is still unknown. Available
evidences suggest that cocaine administration results in acute hyperthermia and alterations …

Oxidative stress (OS) generates or intensifies cocaine-evoked toxicity in the brain and
peripheral organs. The aim of this study was to examine superoxide dismutase (SOD) …

Drug addiction is a public health and social burden. Presently, the most abused illicit
substance is cannabis, followed by amphetamines, cocaine and opioids, with different …