Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major
signals that relay the status of fat stores to the hypothalamus and plays a significant role in …

Energy homeostasis is controlled by a complex neuroendocrine system consisting of
peripheral signals like leptin and central signals, in particular, neuropeptides. Several …

Consumption of dietary fats is amongst the most important environmental factors leading to
obesity. In rodents, the consumption of fat-rich diets blunts leptin and insulin anorexigenic …

The adipose tissue-derived hormone leptin regulates energy balance and neuroendocrine
function. Resistance to the appetite-suppressing effects of leptin is associated with common …

While many questions remain unanswered, it is now well documented that, contrary to
earlier views, insulin is an important neuromodulator, contributing to neurobiological …

Plasma insulin enters the CNS where it interacts with insulin receptors in areas that are
related to energy homeostasis and elicits a decrease of food intake and body weight. Here …

Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic
neurons that transduce hormonal, nutrient and neuronal signals into responses that …

Obesity is important in the aetiology of type 2 diabetes, and presents a major barrier to its
successful prevention and management. Obesity develops when energy intake exceeds …

The hormones insulin and leptin have been demonstrated to act in the central nervous
system (CNS) as regulators of energy homeostasis at medial hypothalamic sites. In a …

The central nervous system is essential in maintaining energy and glucose homeostasis. In
both animals and humans, efficient cerebral insulin signalling is a pivotal control element in …