Targeted alpha therapy: progress in radionuclide production, radiochemistry, and applications
This review outlines the accomplishments and potential developments of targeted alpha (α)
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …
particle therapy (TAT). It discusses the therapeutic advantages of the short and highly …
α-emitters for radiotherapy: from basic radiochemistry to clinical studies—part 1
S Poty, LC Francesconi, MR McDevitt… - Journal of Nuclear …, 2018 - Soc Nuclear Med
With a short particle range and high linear energy transfer, α-emitting radionuclides
demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides …
demonstrate high cell-killing efficiencies. Even with the existence of numerous radionuclides …
A critical review of alpha radionuclide therapy—how to deal with recoiling daughters?
This review presents an overview of the successes and challenges currently faced in alpha
radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared …
radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared …
Leveraging Bioorthogonal Click Chemistry to Improve 225Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma
Purpose: Interest in targeted alpha-therapy has surged due to α-particles' high cytotoxicity.
However, the widespread clinical use of this approach could be limited by on-/off-target …
However, the widespread clinical use of this approach could be limited by on-/off-target …
[HTML][HTML] Radiotherapy controversies and prospective in head and neck cancer: a literature-based critical review
F De Felice, A Polimeni, V Valentini, O Brugnoletti… - Neoplasia, 2018 - Elsevier
In treating head and neck cancer (HNC), the objectives are provided for best functional
results and minimal risk of serious complications. The choice of appropriate management …
results and minimal risk of serious complications. The choice of appropriate management …
Alpha dose modeling in diffusing alpha‐emitters radiation therapy—Part I: single‐seed calculations in one and two dimensions
G Heger, A Roy, M Dumančić, L Arazi - Medical Physics, 2023 - Wiley Online Library
Abstract Background Diffusing alpha‐emitters Radiation Therapy (“DaRT”) is a new method,
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …
presently in clinical trials, which allows treating solid tumors by alpha particles. DaRT relies …
[HTML][HTML] Initial safety and tumor control results from a “first-in-human” multicenter prospective trial evaluating a novel alpha-emitting radionuclide for the treatment of …
A Popovtzer, E Rosenfeld, A Mizrachi, SR Bellia… - International Journal of …, 2020 - Elsevier
Purpose Our purpose was to report the feasibility and safety of diffusing alpha-emitter
radiation therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting …
radiation therapy (DaRT), which entails the interstitial implantation of a novel alpha-emitting …
The potentiation of anti-tumor immunity by tumor abolition with alpha particles, protons, or carbon ion radiation and its enforcement by combination with …
Y Keisari, I Kelson - Cells, 2021 - mdpi.com
The delivery of radiation therapy (RT) for cancer with intent to cure has been optimized and
standardized over the last 80 years. Both preclinical and clinical work emphasized the …
standardized over the last 80 years. Both preclinical and clinical work emphasized the …
Recent insights in barium-131 as a diagnostic match for radium-223: Cyclotron production, separation, radiolabeling, and imaging
F Reissig, D Bauer, M Ullrich, M Kreller, J Pietzsch… - Pharmaceuticals, 2020 - mdpi.com
Barium-131 is a single photon emission computed tomography (SPECT)-compatible
radionuclide for nuclear medicine and a promising diagnostic match for radium-223/-224 …
radionuclide for nuclear medicine and a promising diagnostic match for radium-223/-224 …
Theranostic Imaging Surrogates for Targeted Alpha Therapy: Progress in Production, Purification, and Applications
This article highlights recent developments of SPECT and PET diagnostic imaging
surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the …
surrogates for targeted alpha particle therapy (TAT) radiopharmaceuticals. It outlines the …