Ras homolog gene family member A (RhoA) is a small GTPase of the Rho family involved in
regulating multiple signal transduction pathways that influence a diverse range of cellular …

Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

The'invisible hand'is a term originally coined by Adam Smith in The Theory of Moral
Sentiments to describe the forces of self-interest, competition and supply and demand that …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in
diverse organisms. Here we review findings from budding and fission yeasts that reveal both …

Asymmetric cell division, which includes cell polarization and cytokinesis, is essential for
generating cell diversity during development. The budding yeast Saccharomyces cerevisiae …

The GDP dissociation inhibitors (GDIs) are pivotal regulators of Rho GTPase function. GDIs
control the access of Rho GTPases to regulatory guanine nucleotide exchange factors and …

▪ Abstract Members of the Rho family of small Ras-like GTPases—including RhoA,-B, and-C,
Rac1 and-2, and Cdc42—exhibit guanine nucleotide-binding activity and function as …

Cdc42p is an essential GTPase that belongs to the Rho/Rac subfamily of Ras-like GTPases.
These proteins act as molecular switches by responding to exogenous and/or endogenous …

The small G proteins of the Ras family act as bimodal relays in the transfer of intracellular
signals. This is a dynamic phenomenon involving a cascade of protein–protein interactions …