The prefrontal cortex (PFC) is not only important in executive functions, but also pain
processing. The latter is dependent on its connections to other areas of the cerebral …

The dorsolateral prefrontal cortex (DLPFC) is a functionally and structurally heterogeneous
region and a key node of several brain networks, implicated in cognitive, affective, and …

Chronic pain is one of the most prevalent health problems in our modern world, with millions
of people debilitated by conditions such as back pain, headache and arthritis. To address …

Cognitive impairment is commonly associated with the pain experience. This impairment
represents a major obstacle to daily activities and rehabilitation, especially in the chronic …

CONTEXT: The perception of pain due to an acute injury or in clinical pain states undergoes
substantial processing at supraspinal levels. Supraspinal, brain mechanisms are …

Clinical pain is a serious public health issue. Treatment of pain-related suffering requires
knowledge of how pain signals are initially interpreted and subsequently transmitted and …

The role of the brain in chronic pain conditions remains speculative. We compared brain
morphology of 26 chronic back pain (CBP) patients to matched control subjects, using …

In this review, we integrate recent human and animal studies from the viewpoint of chronic
pain. First, we briefly review the impact of chronic pain on society and address current pitfalls …

Frontal lobe activity during pain is generally linked to attentional processing. We addressed
the question of whether 'bottom‐up'processing and 'top‐down'modulation of nociceptive …

The state of our understanding of the interaction between pain and the brain is undergoing a
veritable revolution, with new surprising observations accumulating at a fast pace. A cursory …