Dysregulated lipid metabolism represents an important metabolic alteration in cancer. Fatty
acids, cholesterol, and phospholipid are the three most prevalent lipids that act as energy …

Pyruvate is irreversibly decarboxylated to acetyl coenzyme A by mitochondrial pyruvate
dehydrogenase complex (PDC). Decarboxylation of pyruvate is considered a crucial step in …

Senescent cells remain metabolically active, but their metabolic landscape and resulting
implications remain underexplored. Here, we report upregulation of pyruvate …

Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

Cancer cells use alterations of normal metabolic processes to sustain proliferation
indefinitely. Transcriptional and posttranscriptional control of the pyruvate dehydrogenase …

Cancer is also determined by the alterations of oncogenes and tumor suppressor genes.
These gene expressions can be regulated by microRNAs (miRNA). At this point, researchers …

A metabolic shift from oxidative phosphorylation (OXPHOS) to glycolysis—known as the
Warburg effect—is characteristic for many cancers. It gives the cancer cells a survival …

The protumor roles of alternatively activated (M2) tumor-associated macrophages (TAMs)
have been well established, and macrophage reprogramming is an important therapeutic …

Found in all organisms, pyruvate dehydrogenase complexes (PDC) are the keystones of
prokaryotic and eukaryotic energy metabolism. In eukaryotic organisms these multi …

The development of chemoresistance remains a major challenge that accounts for colorectal
cancer (CRC) lethality. Dichloroacetate (DCA) was originally used as a metabolic regulator …