[HTML][HTML] The potential mechanism of postoperative cognitive dysfunction in older people

X Lin, Y Chen, P Zhang, G Chen, Y Zhou, X Yu - Experimental gerontology, 2020 - Elsevier
Postoperative cognitive dysfunction (POCD) is a common disorder following surgery, which
seriously threatens the quality of patients' life, especially the older people. Accumulating …

[HTML][HTML] State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018

E Mahanna-Gabrielli, KJ Schenning, LI Eriksson… - British journal of …, 2019 - Elsevier
Cognitive recovery after anaesthesia and surgery is a concern for older adults, their families,
and caregivers. Reports of patients who were 'never the same'prompted a scientific inquiry …

Postoperative delirium and neurocognitive disorders

A Migirov, P Chahar, K Maheshwari - Current opinion in critical …, 2021 - journals.lww.com
A spectrum of NCD exists in surgical patients ranging from postoperative delirium, delayed
neurocognitive recovery, and POCD. Identification of patients at-risk for developing NCD can …

Effects of dexmedetomidine anesthesia on early postoperative cognitive dysfunction in elderly patients

W Wang, Y Ma, Y Liu, P Wang, Y Liu - ACS Chemical …, 2022 - ACS Publications
The stimulation of tracheal extraction and anesthesia may lead to early postoperative
cognitive dysfunction (POCD) in elderly patients, especially within 72 h after surgery, due to …

Postoperative cognitive dysfunction in clinical practice

EA Brodier, M Cibelli - BJA education, 2021 - bjaed.org
Advanced age in surgical patients is accompanied by lifealtering and costly complications.
This challenge is keenly felt in high-income countries, where the mean age for elective …

Postoperative cognitive dysfunction: an acute approach for the development of novel treatments for neuroinflammation

KT Granger, JH Barnett - Drug Discovery Today, 2021 - Elsevier
Highlights•Inflammation in the brain occurs in many CNS disorders (eg, Alzheimer's
disease).•No effective neuroinflammatory treatments currently exist.•POCD may serve as an …

Age-related perioperative neurocognitive disorders: experimental models and Druggable targets

OL Barreto Chang, KL Possin… - Annual Review of …, 2023 - annualreviews.org
With the worldwide increase in life span, surgical patients are becoming older and have a
greater propensity for postoperative cognitive impairment, either new onset or through …

The effect and optimal dosage of dexmedetomidine plus sufentanil for postoperative analgesia in elderly patients with postoperative delirium and early postoperative …

W Zhao, Y Hu, H Chen, X Wang, L Wang… - Frontiers in …, 2020 - frontiersin.org
Background Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD)
are common complications after major surgery among elderly patients. Dexmedetomidine …

Biomarkers and postoperative cognitive function: could it be that easy?

ST Schaefer, S Koenigsperger, C Olotu… - Current Opinion in …, 2019 - journals.lww.com
Single markers for postoperative cognitive impairment cannot predict POD/POCD in geriatric
patients. However, a wisely arranged battery of promising biomarkers might achieve a …

Incidence and factors related to prolonged postoperative cognitive decline (POCD) in elderly patients following surgery and anaesthesia: a systematic review

NR Arefayne, YW Berhe… - Journal of Multidisciplinary …, 2023 - Taylor & Francis
Aim The aim of this systematic review is to explore the current literature to provide evidence
regarding the incidence and risk factors of prolonged POCD in elderly patients following …