Adaptive mechanisms of tumor therapy resistance driven by tumor microenvironment
Cancer is a disease which frequently has a poor prognosis. Although multiple therapeutic
strategies have been developed for various cancers, including chemotherapy, radiotherapy …
strategies have been developed for various cancers, including chemotherapy, radiotherapy …
Focal adhesion signaling and therapy resistance in cancer
Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …
Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy
The safe and effective delivery of drugs is a major obstacle in the treatment of ischemic
stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the …
stroke. Exosomes hold great promise as an endogenous drug delivery nanosystem for the …
[PDF][PDF] In situ formation of nanofibers from purpurin18‐peptide conjugates and the assembly induced retention effect in tumor sites
DOI: 10.1002/adma. 201502598 might effectively improve their bioavailability and treatment
outcomes. Herein, we rationally designed a responsive smallmolecule precursor (P18 …
outcomes. Herein, we rationally designed a responsive smallmolecule precursor (P18 …
Adaptive control of nanomotor swarms for magnetic-field-programmed cancer cell destruction
Magnetic nanomotors (MNMs), powered by a magnetic field, are ideal platforms to achieve
versatile biomedical applications in a collective and spatiotemporal fashion. Although the …
versatile biomedical applications in a collective and spatiotemporal fashion. Although the …
Integrin-linked kinase–essential roles in physiology and cancer biology
PC McDonald, AB Fielding… - Journal of cell …, 2008 - journals.biologists.com
Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions
and regulates many cellular processes, including growth, proliferation, survival …
and regulates many cellular processes, including growth, proliferation, survival …
l-Thyroxine vs. 3,5,3′-triiodo-l-thyronine and cell proliferation: activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
HY Lin, M Sun, HY Tang, C Lin… - … of Physiology-Cell …, 2009 - journals.physiology.org
3, 5, 3′-Triiodo-l-thyronine (T3), but not l-thyroxine (T4), activated Src kinase and,
downstream, phosphatidylinositol 3-kinase (PI3-kinase) by means of an αvβ3 integrin …
downstream, phosphatidylinositol 3-kinase (PI3-kinase) by means of an αvβ3 integrin …
Ionizing radiations sustain glioblastoma cell dedifferentiation to a stem-like phenotype through survivin: possible involvement in radioresistance
P Dahan, J Martinez Gala, C Delmas, S Monferran… - Cell death & …, 2014 - nature.com
Glioblastomas (GBM) are some bad prognosis brain tumors despite a conventional
treatment associating surgical resection and subsequent radio-chemotherapy. Among these …
treatment associating surgical resection and subsequent radio-chemotherapy. Among these …
Glioblastoma stem cells microenvironment: the paracrine roles of the niche in drug and radioresistance
A Fidoamore, L Cristiano, A Antonosante… - Stem cells …, 2016 - Wiley Online Library
Among all solid tumors, the high‐grade glioma appears to be the most vascularized one. In
fact,“microvascular hyperplasia” is a hallmark of GBM. An altered vascular network …
fact,“microvascular hyperplasia” is a hallmark of GBM. An altered vascular network …
Membrane receptor for thyroid hormone: physiologic and pharmacologic implications
PJ Davis, FB Davis, SA Mousa… - Annual review of …, 2011 - annualreviews.org
Plasma membrane integrin αvβ3 is a cell surface receptor for thyroid hormone at which
nongenomic actions are initiated. L-thyroxine (T4) and 3, 3′, 5-triiodo-L-thyronine (T3) …
nongenomic actions are initiated. L-thyroxine (T4) and 3, 3′, 5-triiodo-L-thyronine (T3) …