ABSTRACT Elabela (ELA), Apela or Toddler peptide is a hormone peptide belonging to the
adipokine group and a component of apelinergic system, discovered in 2013-2014. Given its …

Apelin, a bioactive peptide that serves as an endogenous ligand for the apelin receptor
(APJ), is overexpressed in various types of cancers and contributes to cancer cell …

Background: While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on
cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are …

With the adjustment of human diet and lifestyle changes, the prevalence of obesity is
increasing year by year. Obesity is closely related to the excessive accumulation of white …

Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand
among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor …

Urotensin-II is a polypeptide ligand with neurohormone-like activity. It mediates downstream
signaling pathways through G-protein-coupled receptor 14 (GPR14) also known as …

Coronary microvascular dysfunction is prevalent among people with diabetes and is
correlated with cardiac mortality. Compromised endothelial-dependent dilation (EDD) is an …

Abstract Cytoskeleton-associated protein 4 (CKAP4) is a non-glycosylated type II
transmembrane protein that serves as a cell surface-activated receptor. It is expressed …

Rationale Coronary collateral growth is a natural bypass for ischemic heart diseases. It
offers tremendous therapeutic benefit, but the process of coronary collateral growth …

Angiotensin II protein J receptor, APJ, is a type AG protein coupled receptor. Endogenous
apelin and elabela peptides stimulate APJ via distinct signalling profiles. A complex …