Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

A defining characteristic of damage induced in the DNA by ionizing radiation (IR) is its
clustered character that leads to the formation of complex lesions challenging the cellular …

DNA chromosomal DSBs (double-strand breaks) are potentially hazardous DNA lesions,
and their accurate repair is essential for the successful maintenance and propagation of …

Telomeres are present at the ends of all eukaryotic chromosomes. Human telomeres play an
important role in critical processes underlying genome stability, cancer, and aging, and their …

Abstract The mammalian Mre11–Rad50–Nbs1 (MRN) complex coordinates double-strand
break signaling with repair by homologous recombination and is associated with the H2A. X …

DNA double-strand breaks (DSBs) are among the most deleterious forms of DNA lesions in
cells. Here we induced site-specific DSBs in yeast cells and monitored chromatin dynamics …

A‐type lamins are intermediate filament proteins that provide a scaffold for protein
complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked …

Comparative genomics of parasitic protists and their free-living relatives are profoundly
impacting our understanding of the regulatory systems involved in transcription and …

BACKGROUND Complex chromosomal rearrangements (CCRs) describe structural
rearrangements, essentially translocations, involving at least three breakpoints on two or …

In eukaryotic cells, repair of DNA double-strand breaks (DSBs) by the nonhomologous end-
joining (NHEJ) pathway is critical for genomic stability. A functionally homologous repair …