Experimental mouse models for hepatocellular carcinoma research

F Heindryckx, I Colle… - International journal of …, 2009 - Wiley Online Library
Every year almost 500,000 new patients are diagnosed with hepatocellular carcinoma
(HCC), a primary malignancy of the liver that is associated with a poor prognosis. Numerous …

Hepatitis B virus-related hepatocellular carcinoma: paradigms for viral-related human carcinogenesis

D Kremsdorf, P Soussan, P Paterlini-Brechot… - Oncogene, 2006 - nature.com
As discussed in detail in other chapters of this review, chronic hepatitis B (HBV) infection is a
major risk factor for hepatocellular carcinoma (HCC). Most HCCs complicate the evolution of …

Hepatitis B virus-induced hepatocellular carcinoma

C Xu, W Zhou, Y Wang, L Qiao - Cancer letters, 2014 - Elsevier
Many factors are considered to contribute to hepatitis B virus (HBV) associated
hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation …

[HTML][HTML] Anticancer and cytotoxic properties of the latex of Calotropis procera in a transgenic mouse model of hepatocellular carcinoma

T Choedon, G Mathan, S Arya, VL Kumar… - World Journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To evaluate the anticancer property of the dried latex (DL) of Calotropis procera, a
tropical medicinal plant, in the X15-myc transgenic mouse model of hepatocellular …

Chronic viral hepatitis and its association with liver cancer

T Tu, S Bühler, R Bartenschlager - Biological chemistry, 2017 - degruyter.com
Chronic infection with hepatitis viruses represents the major causative factor for end-stage
liver diseases, including liver cirrhosis and primary liver cancer (hepatocellular carcinoma …

Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma

S De Minicis, T Kisseleva, H Francis, GS Baroni… - Digestive and Liver …, 2013 - Elsevier
Hepatocellular carcinoma and cholangiocarcinoma are primary liver cancers, both represent
a growing challenge for clinicians due to their increasing morbidity and mortality. In the last …

Hepatocellular carcinoma: insight from animal models

Y Li, ZY Tang, JX Hou - Nature reviews Gastroenterology & hepatology, 2012 - nature.com
Hepatocellular carcinoma (HCC) ranks as the third most common cause of death from
cancer worldwide. Although major risk factors for the development of HCC have been …

c-MYC—Making liver sick: Role of c-MYC in hepatic cell function, homeostasis and disease

K Zheng, FJ Cubero, YA Nevzorova - Genes, 2017 - mdpi.com
Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell
function, was identified. In recent years, a considerable increment in the number of …

Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma

T Choedon, SK Shukla, V Kumar - Journal of ethnopharmacology, 2010 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: Butea monosperma (Lam.)(Fabaceae)
popularly known as 'flame of the forest'has been widely used in the traditional Indian …

Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC): molecular mechanisms and novel paradigms

C Brechot, D Kremsdorf, P Soussan, P Pineau… - Pathologie …, 2010 - Elsevier
Chronic hepatitis B (HBV) infection is a major risk factor for hepatocellular carcinoma (HCC).
Most HCCs complicate the evolution of an active or inactive cirrhosis. However, some …